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KMID : 0360319730080010001
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Journal of Korean Cancer Research Association
1973 Volume.8 No. 1 p.1 ~ p.12
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TRANSFORMATION OF GUINEA PIG CELLS BY MURINE SARCOMA VIRUS
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:Rhim Johng-S.
저자없음:No authors listed
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Abstract
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Transformation of guinea pig cells by murine sareoma virus (MSV) was studied. Guinea pig(GP) cells were transformed in vitro by the Kirsten strain of MSV (Ki-MSV). The transEormed cells were found to relense infectious virus continuaualy and produced group-specific complement-fixing antigen characteristics of the murine leukemla-sarcoma virus complex. All the focus-derived lines were found to be either producers or nonpro- ducers (NP). The NP guinea pig cells produccd neither virus nor viral antigens. However, the sarcoma virus genome could be rescued in these NP cells by cocultivation with "helper" murine leukemia virus (MuLV) releasing GP cell. Thus, these findings presents evidenee that MSV can transform GP eells in the absence of MuLV, but that MuLV is required for the replieation of infectious MSV particles. Studies on the host range of Ki-MSV indicate that members of the murine sarcoma-leukemia virus complex, particularly Ki-MSV, exhibit a wider host range than was hitherto believed. Particles resembling guinea pig leukemia virus were activated from guinea pig GP cells or eultured normal GP cells following chemieal treatment.
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